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Profitability lever 2 of 3

Follow the Conditions.

Coverage alone does not determine access.

Formulary position, utilization management, prior authorization, step edits, affordability, channel and contracting decide whether theoretical access becomes actual therapy.

The distinction that matters

Your approval rate is not your access rate. It describes the prescriptions that survived long enough to be measured.

Approval counts the prescriptions that made it through. It says nothing about the ones that stopped at authorization, were abandoned at the counter, or never started because the path looked too hard.

5 Layers of GTN™

Access sets the conditions. Finance carries the result.

The 5 Layers are sequential and causal. Each flows into the next, which is why an access decision made in Phase 1 is still showing up in Gross-to-Net in Phase 3.

Layer 1Clinical & Product Foundation
Layer 2Access & Policy
Layer 3Channel & Distribution
Layer 4Affordability & Patient Support
Layer 5Financial Visibility & Enterprise Performance
Access sets the conditions
Finance carries the result

Growth strategy

Access at all costs buys availability, not profitability.

Over or under, the result is the same: uptake and market penetration fall short. The work is finding the band in between.

Under-investment

Insufficient resourcesLimited marketing and promotion leave prescribers and patients unaware, and uptake slows.
Inadequate market accessThin payer negotiations and distribution infrastructure restrict affordability, access and availability.
The investment loopA blue arrow and a magenta arrow circle a capsule in a continuous loop, while the active ingredient particles inside the capsule drift and spill downward.

Over-investment

Wasted resourcesStrategies built without a clear read of market dynamics and customer preferences rarely generate the awareness they pay for.
Reduced returnAccess spending beyond what broad availability and affordability require brings diminishing returns.

Forecast the revenue deductions first. Then judge performance on what the product actually nets.

Illustrative use case

Volume grew. Net price did not.

A brand in its second year added patients every quarter while Gross-to-Net eroded faster than volume grew. Every contract had been signed on purpose. Nobody had looked at what each reimbursement instance actually cost.

Volume up, net price downAcross eight quarters, prescription volume rises steadily while net price per prescription falls.Q1Q2Q3Q4Q5Q6Q7Q8Prescription volumeNet price per prescription
Illustrative shape, not client data.

What was happening underneath

Support drained

Copay support was absorbed by accumulator plans without extending days on therapy.

Invoices unvalidated

Commercial GPO invoices and chargebacks were paid without line-level checks against the contract.

Default routing

Prescriptions settled into whichever eligible channel they reached first, not the one that kept the most net.

How Novus Proximus answers it

Advisory that turns the problem into a plan with owners.

  1. 01Map every pathEvery way the brand can be reimbursed, and exactly what each path deducts.
  2. 02Validate before payingGPO invoices and chargebacks checked against the contract record and member eligibility.
  3. 03Set routing rulesBy plan, channel and program eligibility, so each instance lands on its best eligible path.
  4. 04Measure per instanceNet price per reimbursement instance, reported alongside the quarterly average.

Key concepts

An illustrative composite, not a specific client.

The problem

Most commercialization models were not designed. They evolved. Vendors, programs and channel arrangements were added one at a time until the whole became complexity no one can fully map, and the access assumptions underneath were set before any of it was tested.

What we do

We pressure-test access assumptions against how the category has actually behaved, then design the channel and distribution model on purpose, including Life Sciences Channel Redesign™, so new capabilities are added by design rather than by reaction.

Focus areas

  1. Payer and formulary assumptions tested against category precedent
  2. Net price optimization for every reimbursement instance
  3. Utilization management, prior authorization and step edits
  4. Channel and distribution architecture
  5. GPO and payer contract management, validation and member reporting
  6. Patient-support program integration

Where this shows up first

Access decisions become financial outcomes.

What is agreed at the formulary table is paid for later in rebates, copay support and channel fees.